Tag Archives: Neurological

PTSD as a “Diagnosis of Convenience”: Mefloquine, Tafenoquine and the Prevalence of Neuropsychiatric Disorders in ADF Veterans of East Timor and Bougainville

One of the problems that has perplexed many Australian government officials and veterans advocates in recent years is the disproportionately high number of Australian Defence Force (ADF) East Timor veterans who have been diagnosed with post-traumatic stress disorder (PTSD). PTSD is … Continue reading

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Featured Research – J. Livezey et al, Prolonged Neuropsychiatric Symptoms in a Military Service Member Exposed to Mefloquine

“A 32-year-old male developed neuropsychiatric symptoms 2 weeks after starting mefloquine 250 mg/week for malaria prophylaxis. He continued to take the medication for the next 4 months. Initial symptoms included vivid dreams and anxiety, as well as balance problems. These symptoms persisted and … Continue reading

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Featured Research (2004) – G. S. Dow et al, The Antimalarial Potential of 4-Quinolinecarbinolamines May be Limited Due to Neurotoxicity and Cross-resistance in Mefloquine-resistant P Falciparum Strains

The clinical potential of mefloquine has been compromised by reports of adverse neurological effects. A series of 4-quinolinecarbinolamines were compared in terms of neurotoxicity and antimalarial activity in an attempt to identify replacement drugs.   Neurotoxicity (MTT [thiazolyl blue reduction] … Continue reading

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CDC Staff Accused Injured U.S. Veteran of “Malingering” in Response to Official Drug Regulator Safety Warning on Mefloquine

FDA Black Box Warning In 2013 the U.S. Food and Drug Administration (FDA) issued a “black box” warning regarding the safety of the anti-malarial drug mefloquine. This is the most serious warning issued by the FDA, which in this case … Continue reading

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British Parliamentary Inquiry Report on the Use of Lariam™ (Mefloquine) for Military Personnel to be Published on 24 May 2016

The British Parliament’s Defence Select Committee is publishing its report, “An acceptable risk? The use of Lariam for military personnel” on Tuesday 24 May 2016 at 00.01am. Report This is the Committee’s Fourth Report of Session 2015–16 (HC 567) and it can … Continue reading

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Stuart McCarthy – Diagnosis and Management of Mefloquine Toxicosis in Military Veterans, Part 1

Mefloquine toxicosis, or “mef tox”, is a serious health problem that probably afflicts many tens of thousands of military veterans globally. The anti-malarial drug mefloquine (or Lariam™), like several other drugs from the same family of synthetic quinolines, is known … Continue reading

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Featured Research (2014) – Remington L. Nevin, Mefloquine and Post-traumatic Stress Disorder

Mefloquine (previously marketed in the United States as Lariam [F Hoffmann-LaRoche Ltd, Basel, Switzerland]) is a neurotoxic quinoline-derivative originally developed by the US military for treatment and prophylaxis of malaria. Originally the US military’s preferred antimalarial drug, mefloquine has been widely … Continue reading

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Featured Research – Remington L. Nevin, Rational Risk-Benefit Decision-Making in the Setting of Military Mefloquine Policy

Abstract “Mefloquine is an antimalarial drug that has been commonly used in military settings since its development by the US military in the late 1980s. Owing to the drug’s neuropsychiatric contraindications and its high rate of inducing neuropsychiatric symptoms, which … Continue reading

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Feature Story – Mefloquine and the Canadian Airborne Regiment in the “Somalia Affair” 1993

“This is not who I am, John.” Private Kyle Brown, Canadian Army, 1993 In 1993 Canadian soldier John Dowe deployed to Somalia with the Canadian Airborne Regiment. During this deployment the soldiers were used as subjects in an unethical mefloquine drug trial. … Continue reading

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