Tag Archives: Antimalarial

Scientific Misconduct in the Australian Army Malaria Institute’s Clinical Trials of Tafenoquine – Part 1

The New Mefloquine? Mefloquine is now well known to be neurotoxic, one of several synthetic quinolines able to cause acute psychotic reactions and/or a chronic central nervous system (CNS) toxicity syndrome in a significant proportion of people given these drugs … Continue reading

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Featured Research (2004) – G. S. Dow et al, The Antimalarial Potential of 4-Quinolinecarbinolamines May be Limited Due to Neurotoxicity and Cross-resistance in Mefloquine-resistant P Falciparum Strains

The clinical potential of mefloquine has been compromised by reports of adverse neurological effects. A series of 4-quinolinecarbinolamines were compared in terms of neurotoxicity and antimalarial activity in an attempt to identify replacement drugs.   Neurotoxicity (MTT [thiazolyl blue reduction] … Continue reading

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Philippa Tuckman – Lariam for Military Personnel: An Unacceptable Risk

The House of Commons Defence Committee will publish its report An acceptable risk? The use of Lariam for military personnel  on 24thMay. Having both given evidence to the inquiry and carefully considered the submissions of other witness, I am hopeful … Continue reading

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CDC Staff Accused Injured U.S. Veteran of “Malingering” in Response to Official Drug Regulator Safety Warning on Mefloquine

FDA Black Box Warning In 2013 the U.S. Food and Drug Administration (FDA) issued a “black box” warning regarding the safety of the anti-malarial drug mefloquine. This is the most serious warning issued by the FDA, which in this case … Continue reading

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Daily Express: Ministry of Defence Accused of ‘Negligence on a Grand Scale’ As Troops Sue Over Lariam (Mefloquine)

BRITISH troops who say they were left with serious mental health side effects after taking a controversial anti-malaria drug are taking legal action against the Ministry of Defence. The group of armed forces veterans say they have suffered hallucinations, severe … Continue reading

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British Parliamentary Inquiry Report on the Use of Lariam™ (Mefloquine) for Military Personnel to be Published on 24 May 2016

The British Parliament’s Defence Select Committee is publishing its report, “An acceptable risk? The use of Lariam for military personnel” on Tuesday 24 May 2016 at 00.01am. Report This is the Committee’s Fourth Report of Session 2015–16 (HC 567) and it can … Continue reading

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BBC News: Ministry of Defence Faces Legal Claims Over Malaria Drug Lariam (Mefloquine)

A group of military personnel are seeking damages from the Ministry of Defence over an anti-malarial drug they say has caused mental health problems. Law firm Irwin Mitchell says it has formally notified the MoD of several claims after being … Continue reading

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Feature Story (2004) – Veterans Affairs Alerts Doctors to Malaria Drug Concerns

WASHINGTON, June 24 (UPI) — The Department of Veterans Affairs is warning doctors to watch for long-term mental problems and other health effects from an anti-malaria drug given to soldiers in Afghanistan and Iraq. The drug is mefloquine, known by … Continue reading

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Roche Shareholders: “Lariam Does Not Fit in with Roche’s Image”

Serious concerns over the safety of mefloquine (Lariam™) have not been limited to veterans, travellers or other consumers who have been adversely affected by the drug’s neurotoxic side effects. For many years, shareholders of the multinational Swiss manufacturer of the … Continue reading

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