Category Archives: Research

Congressman John Carter Proposes Support for Mefloquine Veterans by the U.S. Defense Centers of Excellence

The National Defense Authorization Act for Fiscal Year 2017 is currently being debated in U.S. Congress. During this debate Congressman John Carter (Texas) has proposed additional controls on the use of mefloquine by the Department of Defense, and expanding the Defense Centers … Continue reading

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Featured Research (2004) – G. S. Dow et al, The Antimalarial Potential of 4-Quinolinecarbinolamines May be Limited Due to Neurotoxicity and Cross-resistance in Mefloquine-resistant P Falciparum Strains

The clinical potential of mefloquine has been compromised by reports of adverse neurological effects. A series of 4-quinolinecarbinolamines were compared in terms of neurotoxicity and antimalarial activity in an attempt to identify replacement drugs.   Neurotoxicity (MTT [thiazolyl blue reduction] … Continue reading

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British Mefloquine Veteran Resorts to Legal Action: “They Just Put Everything Down to PTSD”

A large proportion of veterans afflicted by mefloquine toxicosis have unfortunately been misdiagnosed with post-traumatic stress disorder (PTSD). Although the symptoms of mefloquine toxicosis can be similar to PTSD, careful examination by health professionals should result in proper diagnosis and … Continue reading

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CDC Staff Accused Injured U.S. Veteran of “Malingering” in Response to Official Drug Regulator Safety Warning on Mefloquine

FDA Black Box Warning In 2013 the U.S. Food and Drug Administration (FDA) issued a “black box” warning regarding the safety of the anti-malarial drug mefloquine. This is the most serious warning issued by the FDA, which in this case … Continue reading

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Roche Shareholders: “Lariam Does Not Fit in with Roche’s Image”

Serious concerns over the safety of mefloquine (Lariam™) have not been limited to veterans, travellers or other consumers who have been adversely affected by the drug’s neurotoxic side effects. For many years, shareholders of the multinational Swiss manufacturer of the … Continue reading

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Feature Story (2013) – Army’s Lariam Expert Funded by Drug Maker

A PROFESSOR who has advised the Department of Defence on its practice of prescribing the Lariam anti-malarial drug to Irish troops has previously received research funding from Roche, its manufacturer. Patricia Schlagenhauf, a pharmacist and editor of the Journal of … Continue reading

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Stuart McCarthy – Diagnosis and Management of Mefloquine Toxicosis in Military Veterans, Part 1

Mefloquine toxicosis, or “mef tox”, is a serious health problem that probably afflicts many tens of thousands of military veterans globally. The anti-malarial drug mefloquine (or Lariam™), like several other drugs from the same family of synthetic quinolines, is known … Continue reading

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Featured Research (2014) – Remington L. Nevin, Mefloquine and Post-traumatic Stress Disorder

Mefloquine (previously marketed in the United States as Lariam [F Hoffmann-LaRoche Ltd, Basel, Switzerland]) is a neurotoxic quinoline-derivative originally developed by the US military for treatment and prophylaxis of malaria. Originally the US military’s preferred antimalarial drug, mefloquine has been widely … Continue reading

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Featured Research (2001) – C. Even, S. Friedman & K. Lanouar, Bipolar Disorder After Mefloquine Treatment

Case report of bipolar disorder in a patient with no personal of family history of psychiatric disorders,  presumably induced by mefloquine. Also see the extensive list of mefloquine related neurological and psychiatric case reports on our research page. C. Even, … Continue reading

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Review of 1998-2014 ADHREC Annual Reports Relating to Trials of Antimalarial Drugs and Vaccines for Tropical Diseases

This is a review paper by Dr Jane Quinn from Charles Sturt University  on the 1998-2014 (inclusive) Australian Defence Human Research Ethics Committee (ADHREC) annual reports relating to trials of antimalarial drugs and vaccines for tropical diseases. The paper provides … Continue reading

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